Uneven front tire wear is described as typical for these cars, attributed in part to the lack of factory camber adjustment (an aftermarket camber kit is the fix for small deviations). The near-600hp output also chews through rear tires quickly, with owners citing intervals in the 15,000-28,000 mile range.
Tire wear, camber, and consumption
Mercedes-Benz E63 AMG (W212) · ownership